Investigator, Discovery Chemistry

The Molecular Modalities Capabilities (MMC) group within Molecular Modalities Discovery (MMD) is currently looking for a motivated and talented chemist to join our team. We are a multidisciplinary team across high-throughput synthesis, analytical chemistry, purification, and automation that collaborates with project teams to progress the discovery and development of new medicines from hit identification through to early development (non-GxP). The purpose of the role is to provide a high level of scientific and technical contributions to projects within the Discovery Chemistry portfolio (including but not limited to: small molecules, PROTACs, degraders, oligonucleotides, covalents, and antibody-drug conjugates) with a primary responsibility of driving efficiencies applying GSK's high throughput experimentation (HTE) platforms through the lens of utilizing the newest technologies in HTE and automation to help invent new processes, systems, and chemistries. The successful candidate will work collaboratively across teams of synthetic chemists, analytical chemists, engineers, and data analytics experts to help invent these new processes and chemistries to solve impactful problems that will accelerate delivery of important medicinal advancements to patients.

Successful candidates must be able to think creatively, champion the needs of the organization and work collaboratively within a team environment. This lab-based role will be expected to demonstrate synthetic chemistry contributions while embedded within program teams or technology development objectives. The successful candidate will also be trained to incorporate data analytic systems, design singleton or arrays of compounds to test medicinal chemistry hypotheses, and enable synthetic efforts through inception, optimization, and execution of synthetic routes.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Design and develop novel automation techniques for HTE-supported applications to support progression of GSK's portfolio of programs.
• Identify opportunities to accelerate program objectives through implementation of automation and HTE techniques while applying principles of medicinal chemistry
• Be an excellent team player within a matrixed organization, working cross-functionally across other departments including but not limited to engineering automation, analytical chemistry, process chemistry, sample management, and molecular biology/assay sciences.
• Application of modern cheminformatics and data analytic approaches to analysis and design of experiments.
• Communication of key results and data to stakeholders and senior managements when necessary
• Interpretation of emerging data and independently propose a modification of plans or hypotheses accordingly.
• Be responsible for patent and publication write-ups when appropriate.

When submitting your CV/Resume please also include a Research Statement

Basic Qualifications

We are looking for professionals with these required skills to achieve our goals:

• Ph.D. in Organic Chemistry, Synthetic Methodology Development, Medicinal Chemistry, or related discipline
• Experience in synthetic chemistry; the application of new synthetic methodology and execution of multi-step syntheses.
• Record of peer-reviewed publications, patents, or presentations

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Postdoctoral experience and/or 1-5+ years industrial experience
• Expertise in both synthetic methodology development and total synthesis
• High-throughput experimentation experience
• Expertise in flow chemistry, electrochemistry, and/or photoredox chemistry
• Data analytics and cheminformatics experience
• Experience or interest in learning data analytics, cheminformatics, and/or programming (SQL, Python, etc.)
• Track record of working effectively in a team environment
• Highly organized with strong attention to detail and a focus on quality results
• Excellent written and oral communication skills
• High learning agility and curiosity to learn and adopt new technologies

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

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